Inner Ecosystem: Elucidating the Gut's Microbial Complexities

Introduction

The gut microbiome, a complex community of microorganisms in our digestive tract, plays a crucial role in our body's functions, such as digestion, immunity, and overall mental health. In this regard, "Inner Ecosystem: Elucidating the Gut's Microbial Complexities" embarks on a journey to uncover the secrets of these microscopic inhabitants. The article explores the multifaceted roles of these microbes and how they contribute to our well-being. Moreover, it delves into the potential consequences of an unbalanced gut microbiome. The latest scientific research will be examined to elucidate the symbiotic relationship between humans and their microbiome. This will shed light on how these tiny organisms profoundly impact our lives.

Defining the Gut Microbiome

At its core, the gut microbiome refers to the vast community of microorganisms in our digestive tract. This includes a diverse array of bacteria, viruses, fungi, and protozoa, each playing a unique role in our body's ecosystem. Far from being mere passengers, these microscopic entities engage in a symbiotic relationship with their human hosts, offering benefits essential for health and survival.

The gut microbiome begins to develop at birth and is influenced by various factors throughout life, including diet, lifestyle, and environmental exposures. It's estimated that the human gut hosts as many as 100 trillion microbial cells, a number that dwarfs the total number of human cells in the body. This vast microbial community contributes to many critical functions, including digestion, nutrient absorption, and synthesising vitamins and amino acids. Moreover, it plays a crucial role in developing and regulating the immune system, helping protect against pathogens and influence the body's inflammatory response.

Each person's gut microbiome is as unique as their fingerprint, shaped by genetics, age, and the environment. This uniqueness contributes to differences in how individuals digest food, respond to medications, and even how susceptible they are to certain diseases. Understanding the composition and function of the gut microbiome is critical to unlocking new ways to treat and prevent disease, making it one of the most exciting frontiers in modern medicine and health research.

As we delve deeper into the intricacies of the gut microbiome, it becomes clear that these microscopic inhabitants are fundamental to our health, affecting everything from our digestion to our mood. By defining and understanding the gut microbiome, we open the door to a new era of personalised medicine and health care tailored to each individual's unique microbial composition.

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Critical Microbes: Pillars of the Gut Ecosystem

In our gut microbiome, certain microbes play a crucial role in maintaining the health and stability of this complex ecosystem. These microbes are known as keystone species and are comparable to the pillars that support and influence the overall structure and functionality of our digestive tract's microbial community, making them stand out.

Keystone species in the gut microbiome are critical for several reasons. They help break down dietary fibres into short-chain fatty acids (SCFAs), compounds that provide energy to gut cells, reduce inflammation, and help regulate the immune system. These critical microbes not only support digestion and absorption of nutrients but also play a crucial role in protecting against diseases by strengthening the gut barrier and influencing systemic immune responses.

Moreover, these species are involved in synthesising essential vitamins like vitamin K and specific B vitamins, vital for blood clotting, energy production, and nerve function. They also help detoxify harmful substances and compete with pathogenic microbes, preventing infections and maintaining a balanced microbial environment conducive to health.

The impact of keystone species extends beyond the gut to influence overall health, including metabolism, obesity, and even mental health through the gut-brain axis. Their presence or absence can signify the health of the gut microbiome, with imbalances often associated with various diseases, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and obesity.

Understanding the role and function of these critical microbes opens the door to targeted interventions, including probiotics and prebiotics designed to support these keystone species, thereby enhancing gut health and, by extension, overall well-being. As research progresses, identifying and supporting these keystone species within the gut microbiome remains vital to developing new disease prevention and treatment strategies.

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Signs of Microbial Imbalance in the Gut

A healthy gut microbiome is all about balance. When this delicate equilibrium is disrupted, it can lead to a condition known as dysbiosis—an imbalance between beneficial and harmful microorganisms in the gut. Recognising the symptoms of gut flora imbalance is crucial for early intervention and restoration of microbial harmony. Here are some key signs that may indicate an imbalance in the gut microbiome:

• Digestive Issues: Frequent bloating, gas, constipation, diarrhea, or heartburn can all be indicators of dysbiosis. These symptoms arise as the gut's microbial composition directly influences the digestive process.
• Unexplained Fatigue: Chronic fatigue and low energy levels can sometimes be linked to an imbalanced gut microbiome, affecting the body's ability to absorb nutrients and produce energy efficiently.
• Skin Conditions: Skin health is surprisingly connected to the gut, with conditions such as eczema, acne, and psoriasis often worsening with microbial imbalance.
• Mood Fluctuations and Mental Health: The gut-brain axis means our microbiome can influence our mental health. Symptoms like anxiety, depression, and mood swings might be connected to dysbiosis.
• Weight Changes: Unexplained weight gain or difficulty losing weight can sometimes be traced back to an imbalanced gut, as the microbiome influences metabolism and the body's ability to process fats and sugars.
• Frequent Infections: An imbalance in the gut microbiome can weaken the immune system, leading to increased susceptibility to infections, including urinary tract infections, colds, and flu.

Recognising these symptoms as potential signs of gut flora imbalance is the first step toward seeking appropriate intervention. It's possible to restore balance and improve overall health through diet changes, probiotics, and sometimes medical treatment. As we learn more about the gut microbiome's intricate role in our well-being, understanding its influence on these symptoms becomes increasingly essential.

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The Gut-Brain Connection: A Complex Dialogue

One of the most ground breaking discoveries in recent science is the intricate communication network known as the gut-brain axis. This bi-directional pathway links the gut's enteric nervous system with the brain's central nervous system. This connection suggests that the state of our gut microbiome can directly influence our mental health and cognitive functions and vice versa. Here's how this complex dialogue plays out:

• Mood and Mental Health: Research has shown that the gut microbiome can produce and influence the levels of neurotransmitters, such as serotonin and dopamine, which play critical roles in regulating mood. Imbalances in the gut microbiota have been linked to conditions like depression and anxiety.
• Stress Response: The gut-brain axis also plays a critical role in how the body responds to stress. Certain gut bacteria can influence the body's stress response, potentially affecting how we cope with stressors.
• Cognitive Functions: Emerging evidence suggests that the gut microbiome may impact cognitive functions, including memory and decision-making processes, though the mechanisms remain under investigation.
• Neurological Conditions: There is increasing interest in the potential role of the gut microbiome in neurological conditions, such as Alzheimer's disease, Parkinson's disease, and autism spectrum disorder, suggesting that microbiome-targeted therapies might offer new treatment avenues.

The discovery of the gut-brain axis opens up a new realm of possibilities for understanding human health and treating various conditions. It emphasises the importance of maintaining a healthy gut microbiome as part of broader strategies to support mental and cognitive health. Nutritional interventions, probiotics, and lifestyle modifications promoting a balanced gut microbiome are increasingly recognised for their potential to impact brain health positively.

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Microbes and Minds: The Gut's Influence on Mental Health

The field of psychobiotics has revealed some compelling discoveries about the impact of our gut microbiome on our mental health. This connection, an extension of the gut-brain axis, indicates that the balance of microbes in our gut plays a vital role in our psychological well-being. Let's delve deeper into how the microscopic organisms in our gut can affect our minds.

• Mood Regulation: A significant portion of the body's serotonin, a neurotransmitter pivotal to mood regulation, is produced in the gut. An imbalance in gut flora can affect serotonin levels, potentially leading to mood disorders such as depression and anxiety.
• Stress and Anxiety: Certain strains of gut bacteria have been found to influence the body's stress response. By modulating the production of stress-related hormones, these microbes can play a role in managing anxiety levels.
• Cognitive Health: Beyond mood and stress, the gut microbiome also influences cognitive functions, including learning, memory, and decision-making processes. Research is exploring how alterations in gut bacteria composition might relate to cognitive decline and neurodegenerative diseases.
• Resilience to Psychological Stress: Emerging evidence suggests that a diverse and balanced gut microbiome may enhance resilience to psychological stress, improving mental health outcomes.

The implications of these findings are profound, offering potential new pathways for treating mental health conditions through dietary and probiotic interventions aimed at restoring gut microbial balance. While research is still in its early stages, manipulating the gut microbiome to support mental health represents a promising frontier in psychology and gastroenterology.

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Nurturing Your Gut: Steps to a Healthier Microbiome

Maintaining or improving the health of your gut microbiome is crucial for both physical and mental well-being. The good news is that simple lifestyle and dietary changes can significantly impact the diversity and balance of your gut bacteria. Here are some effective strategies to nurture a healthy gut microbiome:

• Diverse Diet: Consuming a wide variety of foods, especially high-fibre fruits, vegetables, legumes, and whole grains, can enhance microbial diversity in the gut. These foods provide the necessary nutrients and prebiotics that beneficial bacteria thrive on.
• Probiotics: Incorporating probiotic-rich foods like yogurt, kefir, sauerkraut, and kimchi, or taking a probiotic supplement, can introduce beneficial bacteria to your gut ecosystem.
• Limit Antibiotics: While sometimes necessary for bacterial infections, antibiotics can disrupt the gut microbiome. Use them only when prescribed by a healthcare provider, and discuss probiotic supplementation as a way to mitigate side effects.
• Stay Hydrated: Adequate hydration is essential for maintaining mucosal lining in the gut, which supports the gut bacteria's environment.
• Reduce Stress: Chronic stress can negatively impact gut health. Use stress-reduction techniques such as meditation, yoga, or regular exercise to protect your gut.
• Avoid Unnecessary Additives: Certain food additives, artificial sweeteners, and processed foods can harm beneficial gut bacteria. Opting for whole and minimally processed foods can support microbiome health.
• Get Enough Sleep: Regular, restful sleep is crucial for a healthy gut. Establishing a consistent sleep schedule can help maintain gut microbiome balance.

By adopting these habits, you can foster a thriving gut microbiome, which, in turn, supports your overall health and well-being. Changes don't happen overnight, but consistent efforts can significantly improve gut health.

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Frontiers in Microbiome Research: What's Next?

The gut microbiome exploration stands at the forefront of medical science, offering new insights into human health and disease prevention. As researchers continue to unravel the complexities of the gut's microbial community, the potential for ground breaking therapeutic strategies grows. Here are some key areas of ongoing and future research in gut microbiome science:

• Personalised Nutrition: Advances in microbiome research are paving the way for personalised diet plans based on an individual's gut bacteria composition, which could optimise health and prevent disease.
• Psychobiotics: This emerging field explores how modifying the gut microbiome through specific probiotics can improve mental health outcomes, opening new avenues for treating psychiatric disorders.
• Gut Microbiome as a Disease Marker: Scientists are investigating the gut microbiome's role as a predictive marker for diseases, including cancer, autoimmune disorders, and neurodegenerative diseases, which could revolutionise early detection and treatment strategies.
• Microbiome Restoration Therapies: Research is exploring fecal microbiota transplants (FMT) and other microbiome restoration techniques as treatments for conditions like Clostridium difficile infection, inflammatory bowel disease, and more.
• Microbial Engineering: Advances in genetic engineering may allow for the creating of designer probiotics tailored to combat specific pathogens or produce beneficial compounds directly within the gut.

The horizon of gut microbiome research is vast and promising, with potential benefits extending across multiple facets of medicine and health care. As we continue to learn more about the intricate relationships between our microbiome, diet, lifestyle, and health, the possibilities for enhancing human well-being seem limitless. The journey into the microbial world within us is just beginning, and each discovery brings us closer to harnessing the full potential of our inner ecosystem for better health.

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Boosting Health: Probiotics & Prebiotics' Role

When it comes to achieving optimal health, probiotics and prebiotics are crucial dietary components that help enhance the function and composition of the gut microbiome. They work in tandem to support digestive health and promote the body's healing process. Here's how probiotics and prebiotics work together to boost your health:

• Probiotics: These are live beneficial bacteria found in certain foods and supplements. By adding more good bacteria to the digestive system, probiotics help balance the gut microbiome, supporting immune function, reducing inflammation, and enhancing nutrient absorption. Familiar sources include yogurt, kefir, sauerkraut, tempeh, and miso.
• Prebiotics: Unlike probiotics, prebiotics are not live bacteria but fibres that feed the beneficial bacteria already living in the gut. They help improve the growth and activity of good bacteria, promoting a healthy gut environment. Prebiotics are found in bananas, onions, garlic, leeks, asparagus, artichokes, and whole grains.

Together, probiotics and prebiotics can:

1. Enhance Digestive Health: They contribute to a balanced gut microbiome, which is crucial for efficient digestion and for preventing digestive disorders.
2. Boost Immune Function: A healthy gut microbiome supported by probiotics and prebiotics can improve the body's defence against infections and diseases.
3. Reduce Inflammation: Modulating the gut microbiome can lower systemic inflammation, a cause of many chronic diseases.
4. Support Mental Health: The gut-brain axis means that a healthy gut can influence mood and cognitive functions, reducing symptoms of depression and anxiety.
5. Promote Healing: A balanced microbiome, including recovery from illnesses and even surgeries, is vital for Healing.

Incorporating various probiotic and prebiotic sources into your diet can accelerate Healing and contribute to a robust and resilient gut microbiome. As research continues to reveal the extensive benefits of these gut-friendly aids, their role in preventive health care and therapeutic interventions becomes increasingly significant.

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Navigating Gut Health: FAQs and Professional Guidance

As interest in the gut microbiome's role in overall health continues to grow, so do questions about how to effectively support this complex ecosystem. Understanding the nuances of gut health can empower individuals to make informed decisions, but it's also crucial to recognise when professional guidance is needed. Here are some frequently asked questions and considerations for navigating your journey to optimal gut health:

• Can I test my gut microbiome at home? While at-home microbiome testing kits are available, interpreting these results can be complex. These tests can provide insights into the diversity and abundance of certain bacteria, but translating this information into actionable health strategies is best done with the help of a healthcare professional.
• How quickly can changes to diet affect the gut microbiome? The gut microbiome can promptly respond to dietary changes, often within days. However, establishing and maintaining beneficial changes requires consistent nutritional habits over time.
• Are probiotic supplements as effective as food sources? Probiotic foods and supplements can both be effective. Foods naturally rich in probiotics often contain additional nutrients and dietary fibres (prebiotics) that support gut health. Supplements can be a good option for targeted strains, though it's essential to choose high-quality products based on professional recommendations.
• Is there a one-size-fits-all approach to improving gut health? Due to the unique nature of each person's microbiome, what works for one individual may not work for another. Personalised nutrition and lifestyle changes are more effective and tailored to an individual's health status, dietary preferences, and microbiome composition.

Seeking Professional Guidance:

Given the complexity of the gut microbiome and its influence on health, consulting with healthcare professionals, such as gastroenterologists, dietitians specialising in gut health, or functional medicine practitioners, is crucial. These experts can help interpret test results, tailor dietary recommendations, and address specific health concerns. Moreover, they can guide the use of probiotics and prebiotics, ensuring that any interventions are safe, effective, and aligned with your overall health goals.

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Personalisation: The Keystone of Gut Health

One principle stands out as we journey through the landscape of gut microbiome research and its health implications: personalisation. The unique composition of each person's gut microbiome means there's no one-size-fits-all solution to achieving optimal gut health. This diversity highlights the intricacy of our internal ecosystems and underscores the importance of tailored approaches to diet, probiotics, and lifestyle interventions.

Understanding and nurturing your gut microbiome requires a commitment to this personalised approach. It involves being mindful of how different foods and lifestyle choices affect your body, listening to your gut's signals, and incorporating targeted probiotic and prebiotic strategies based on professional advice.

The Future of Gut Health: A Personal Journey

Looking forward, the evolving field of gut microbiome research promises to deliver even more insights into how we can support our health through personalised strategies. Advances in technology and science will continue to uncover the complex relationships between our microbiome, diet, and overall health, offering new avenues for preventing and treating a wide range of conditions.

The role of healthcare professionals in this dynamic and exciting field cannot be overstated. Collaborating with dietitians, gastroenterologists, and other health experts is critical to navigating the complexities of the gut microbiome. These specialists can offer guidance tailored to your unique health needs and microbiome profile, ensuring that your journey towards optimal gut health is informed and effective.

Embracing the Complexity: A Path to Wellness

The journey towards understanding and improving gut health is unique to each individual and can be full of challenges and discoveries. By acknowledging the complexity of the gut microbiome and adopting personalized gut health strategies, we can make informed decisions that enhance our overall well-being. As we continue to explore this fascinating field, we should remember the principles of diversity, balance, and personalization, knowing that the path to wellness truly begins in the gut.

Consultation with Professionals: Your Guide in the Microbial Maze

The advice of healthcare professionals is crucial in managing gut health and microbiome. It is not recommended to undertake the journey of navigating the gut ecosystem alone, due to its complexity and profound impact on overall health. To achieve wellness, it is necessary to seek a guided approach where expertise can illuminate the path.

Why Professional Guidance Matters

• Personalised Health Strategies: Given the unique nature of each individual's microbiome, generic advice needs to be revised. Healthcare professionals can provide personalised recommendations based on your health history, current conditions, and specific goals.
• Interpreting Microbiome Data: Advanced tests can glimpse your gut's microbial composition, but decoding this information requires expertise. Professionals can help translate data into actionable insights, distinguishing between transient changes and significant patterns.
• Safe and Effective Use of Supplements: The market is flooded with probiotics and prebiotics, each claiming myriad health benefits. A healthcare professional can recommend high-quality products that benefit your specific microbiome makeup.
• Addressing Underlying Health Conditions: Sometimes, gut health-related symptoms may signal deeper medical concerns. A thorough evaluation by a professional can ensure that underlying conditions are noticed.

Finding the Right Professional

Seeking specialists who understand the nuances of the gut microbiome can make all the difference. This might include gastroenterologists, nutritionists, dietitians specialising in gut health, or integrative medicine practitioners. These professionals not only guide you through the complexity of gut health but also ensure that your journey is backed by the latest science and tailored to your body's needs.

The Collaborative Path to Wellness

Collaboration with healthcare professionals empowers you to make informed decisions about your gut health. It transforms the process from a trial-and-error endeavour into a strategic, personalised approach. Whether adjusting your diet, choosing the right probiotics, or addressing specific health concerns, professional guidance is critical to navigating the vast ecosystem within you.

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Navigating Uncertainties: The Limitations of Gut Microbiome Research

The study of the microscopic gut microbiome holds great promise for treating various health conditions. However, it is also essential to recognize this field's significant uncertainties and limitations. Having a balanced understanding of what microbiome research can offer and what challenges lie ahead is crucial.

Emerging Science, Emerging Questions

• Variability and Complexity: The gut microbiome is highly individualised and influenced by genetics, diet, environment, and lifestyle. This variability makes it challenging to create one-size-fits-all recommendations, underscoring the need for personalised approaches.
• Causation vs. Correlation: Current research identifies correlations between specific microbial compositions and health conditions. Distinguishing whether these microbial patterns cause or affect health states remains a significant challenge.
• Long-Term Effects: The long-term impacts of altering the gut microbiome through diet, probiotics, and other interventions are still largely unknown. Research in this area is ongoing, and caution is advised when extrapolating short-term findings to long-term health outcomes.
• Translation to Therapies: Translating findings from gut microbiome research into effective treatments is complex and time-consuming. Each step, from discovery to clinical application, faces hurdles, including ensuring safety, efficacy, and accessibility.

The Path Forward: Research with Caution

The excitement around the gut microbiome's potential must be balanced with a careful and critical approach to research. Scientists and healthcare professionals alike are called to navigate this promising field with an awareness of its limits and a commitment to rigorously testing and validating findings.

A Collaborative Effort

Uncovering the secrets of the gut microbiome and utilizing them to enhance health outcomes necessitates a collaborative effort from researchers, clinicians, and patients. We can all contribute to the progress of this continuously evolving field by participating in ongoing research, taking part in studies, and staying informed.

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Toward a Healthier Inner Ecosystem

Exploring the gut microbiome reveals its profound impact on our health and underscores the journey toward wellness as personal and science-guided. As we navigate this complex terrain, the blend of emerging research and expert consultation offers a pathway to optimising our gut health. Embracing a personalised approach to diet, lifestyle, and probiotics is crucial, reflecting our unique microbial makeup. As research advances, it promises to illuminate the gut's role in our health, inviting us to listen and adapt to our body's needs. Exploring our inner ecosystem reminds us of the delicate balance that sustains us, urging ongoing curiosity and care for our gut health.

Disclaimer:

The information presented in this article is intended for informational purposes only and should not be construed as medical advice or a substitute for professional consultation. While efforts have been made to ensure the accuracy and reliability of the information provided, individual circumstances and health conditions may vary. Readers are encouraged to consult qualified healthcare professionals for personalized advice regarding their health concerns and treatment options. The authors and publishers of this article are not liable for any potential consequences arising from using the information presented herein.

References

• Frontiers in Cellular and Infection Microbiology. (2021, July 6). Gut microbiota in NSAID enteropathy: New insights from inside. Frontiers in Cellular and Infection Microbiology, 11, Article 679396.https://doi.org/10.3389/fcimb.2021.679396
• Xiong, R.-G., Li, J., Cheng, J., Zhou, D.-D., Wu, S.-X., Huang, S.-Y., Saimaiti, A., Yang, Z.-J., Gan, R.-Y., & Li, H.-B. (2023). The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components. Nutrients, 15(14), 3258.https://doi.org/10.3390/nu15143258
• Mihajlovic, J., Leutner, M., Hausmann, B., Kohl, G., Schwarz, J., Röver, H., Stimakovits, N., Wolf, P., Maruszczak, K., Bastian, M., & [et al.]. (2021). Combined hormonal contraceptives are associated with minor changes in composition and diversity in gut microbiota of healthy women. Environmental Microbiology, 23(1), 329-338. 
  https://doi.org/10.1111/1462-2920.15517
• Al Bander, Z., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020). The Gut Microbiota and Inflammation: An Overview. International Journal of Environmental Research and Public Health, 17(20), 7618. https://doi.org/10.3390/ijerph17207618
• Mitrea, L., Nemeş, S.-A., Szabo, K., Teleky, B.-E., & Vodnar, D.-C. (2022). Gut Imbalances Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders. Frontiers in Medicine (Lausanne), 9, 813204. https://doi.org/10.3389/fmed.2022.813204
• Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018). The Brain-Gut-Microbiome Axis. Cellular and Molecular Gastroenterology and Hepatology, 6(2), 133–148. https://doi.org/10.1016/j.jcmgh.2018.04.003
• Cerdó, T., García-Santos, J. A., Bermúdez, M. G., & Campoy, C. (2019). The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients, 11(3), 635.  https://doi.org/10.3390/nu11030635
• Williams, G. M., Tapsell, L. C., & Beck, E. J. (2023). Gut health, the microbiome and dietary choices: An exploration of consumer perspectives. Nutrition & Dietetics, 80(1), 85–94. https://doi.org/10.1111/1747-0080.12769
• Hills, R. D. Jr., Pontefract, B. A., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019). Gut microbiome: Profound implications for diet and disease. Nutrients, 11(7), 1613. https://doi.org/10.3390/nu11071613
• Cullen, C. M., Aneja, K. K., Beyhan, S., Cho, C. E., Woloszynek, S., Convertino, M., McCoy, S. J., Zhang, Y., Anderson, M. Z., Alvarez-Ponce, D., Smirnova, E., Karstens, L., Dorrestein, P. C., Li, H., Sen Gupta, A., Cheung, K., Gloeckner Powers, J., Zhao, Z., & Rosen, G. L. (2020). Emerging priorities for microbiome research. Frontiers in Microbiology, 11, 136. https://doi.org/10.3389/fmicb.2020.00136
• Lu, Y., Wang, R., Zhang, Y., Su, H., Wang, P., Jenkins, A., Ferrier, R. C., Bailey, M., & Squire, G. (2015). Ecosystem health towards sustainability. Ecosystem Health and Sustainability, 1(1), Article e0123456. https://doi.org/10.1890/EHS14-0013.1